The slow Wallerian degeneration gene, Wld, inhibits axonal spheroid pathology in gracile axonal dystrophy mice
نویسندگان
چکیده
Correspondence: Dr Michael Coleman, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK E-mail: [email protected] *W. Mi and B. Beirowski contributed equally to this work ZMMK and Institute for Genetics and Department of Anatomy I, University of Cologne, Cologne, Germany, Division of Neuroscience, University of Edinburgh, Edinburgh, The Babraham Institute, Babraham, Cambridge, UK, Department of Degenerative Neurological Diseases, National Institute of Neuroscience, Kodaira, Tokyo and Clinical Research Institute, Kanagawa Children’s Medical Center, Yokohama, Japan
منابع مشابه
The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice.
Axonal dystrophy is the hallmark of axon pathology in many neurodegenerative disorders of the CNS, including Alzheimer's disease, Parkinson's disease and stroke. Axons can also form larger swellings, or spheroids, as in multiple sclerosis and traumatic brain injury. Some spheroids are terminal endbulbs of axon stumps, but swellings may also occur on unbroken axons and their role in axon loss re...
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Axons are essential, vulnerable and often irreplaceable so it is essential to understand how they are lost in neurodegenerative disease. Recent data link the mechanism of injury-induced Wallerian degeneration to that of axon death in CNS and PNS disease. The neuroprotective gene Wld(S) delays Wallerian degeneration, CNS axonal dystrophy, 'dying-back' pathology and to a lesser extent synapse los...
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The degeneration of axons is the underlying pathological process of several neurological disorders. The Wallerian degeneration (Wld(S)) slow protein, which is primarily nuclear, markedly inhibits axonal degeneration. Contradictory models have been proposed to explain its mechanism, including a role in the nucleus, where it affects gene transcription, and roles outside the nucleus, where it regu...
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